PRIMOBOLAN (METHENOLONE) - PROFILE

Primobolan is a derivative of DHB (dihydroboldenone), class 1 (binds strongly to the androgenic receptor, AR), with possible anti-estrogenic activity.

Primobolan's properties and details were first launched and published in 1960 [1]. Squibb launched the injectable form of Primobolan (Methenolone Enanthate) for the first time in 1962, followed by the launch of the oral variant of Primobolan (Methenolone Acetate) to the North American market in the same year [2]. It was marketed under the brand name Nibal Depot (for the injectable) and Nibal for the oral variant in doses of 20 mg per tablet. Very shortly thereafter, the rights to produce the compost were sold in West Germany to Schering. After this sale of rights, Nibal was withdrawn from the US market and instead, the Schering compound marketed under the new trade name Primobolan (for both variants). Primobolan then essentially became an anabolic steroid manufactured by Schering, which then marketed the compound as an internationally exclusive drug, and never returned to the American market. An interesting point to note is that although Primobolan was never marketed in the United States after Schering bought her rights, it is still listed as an FDA approved drug. This had allowed American doctors to be able to import Primobolan in a special order. Like most anabolic steroids at the time, Primobolan in the early 1990s ended up being withdrawn from all markets and Schering ceased production as a result of the ever-increasing mass hysteria surrounding anabolic steroids and the growing anti-steroid feeling in media of the time. As a result, the pharmaceutical Primobolan manufactured by Schering today is sold only in a small and select number of countries worldwide, such as Turkey, Spain, Japan, Paraguay and Ecuador.

Primobolan (methenolone) is a moderately anabolic and androgenic anabolic steroid (anabolism / androgenicity: 88 / 44-57), and at the highest cost among anabolic steroids [3]. Methenolone is an anabolic steroid with anti-estrogenic properties (it was used to treat breast cancer) [4], and therefore does not aromatize (-1 on the Haluch scale) [5] and it is speculated that it may help to combat side effects caused by aromatization of other drugs such as testosterone, dianabol, etc. (retention, high blood pressure, gynecomastia). This makes Primobolan an excellent drug for defining cycles or aiming for quality gains - although it is not very anabolic - even because it binds strongly to AR (more than testosterone itself) [6], and this makes it a excellent drug for burning fat. The possible side effects with this drug are associated with its androgenicity (acne, hair loss, etc.), but they are usually very mild and tolerated even at high doses (> 500mg per week). Inhibition of the HPT axis is very mild with this drug [7], as well as changes in the lipid profile (HDL, LDL, total cholesterol) [8]. In his Underground Steroids Handbook 2 Dan Duchaine says that primobolan was one of the favorite steroids for older athletes, and also prescribed for therapeutic use in children and women, being very popular because it is one of the safest and smoothest steroids in collateral [9]. Its use for the treatment of anemia and AIDS has also been speculated [7]. Within the medical field, Primobolan is used to treat individuals who suffer from conditions where muscle wasting and severe weight loss is a symptom. Other uses include: an immunostimulant for individuals fighting infections, debilitating conditions, an adjuvant to counteract the effects of long-term corticosteroid therapy, and the treatment of osteoporosis, as well as sarcopenia (loss of muscle mass correlated with aging) [1 ].

With all these characteristics Primobolan is compared by many authors (Bill Roberts, Anthony Roberts) with masteron [3, 7, 10], so it would not be very efficient to combine the two drugs in the same cycle at the same time. Because it is a class 1 steroid Primobolan has a good synergy with class 2 drugs (which act in ways not mediated by the androgen receptor), such as dianabol, hemogenin and stanozolol, so it can be an excellent combination with one of these drugs, in addition to testosterone [ 11].

Because it is a powerful drug for quality gains, very aesthetic, methenolone is often used by many athletes during preparation for competition or in cycles aiming at quality gains. Methenolone can be found in the oral (acetate ester with a half-life of ~ 2-3 hours) and injectable (acetate with a half-life of ~ 2 days, enanthate with a mv of ~ 5 days). The most efficient doses used for the injectable are usually 300 to 500 mg per week, while in its oral version the most efficient doses must be high of ~ 80-100mg per day, even because methenolone acetate is not an alpha-water 17 , but 1-methylated, being slightly toxic to the liver, but also compromising its bioavailability. Women can also use this drug very safely at doses of 100 to 200 mg per week for the enanthate version and at ~ 30 mg per day in the oral version, with a low risk of virilization [12].

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