HCG (human chorionic gonadotropin) is a polypeptide hormone produced in the first months of pregnancy in order to maintain the corpus luteum, and for this reason it is used as a good marker for pregnancy tests. This hormone was discovered in 1920 and over time it was marketed by Organon. Between the 50s and 60s it had several clinical uses, including fertility induction in men and women, cryptorchism, depression and obesity. The use for weight loss treatment was proposed by Dr Simeons in 1954 in combination with a 500kcal diet, but since that time until today studies have shown no difference between the HCG diet and placebo.

HCG mimics the luteinizing hormone (LH), which is released by the pituitary gland, and in men this hormone has the function of stimulating the production of testosterone in the testicles. In male fertility therapy, HCG is used in doses of 3000 to 6000 IU per week, raising testosterone and stimulating spermatogenesis. Many studies show that the use of HCG restores testosterone and fertility in steroid users who have developed hypogonadism after discontinuing the use of anabolic steroids. For this reason, HCG has been used since the 1980s among bodybuilders and has become the main drug of use in post-cycle therapy (PCT). Some gurus and doctors recommend the use at the beginning of PCT in doses of 2000 to 5000 IU per week (first 3-4 weeks, as long as the PCT timing * is respected), while others defend the intra cycle use in doses below 500 -1000UI week, claiming to be more advantageous for recovery of the HPT axis to avoid testicular atrophy during steroid use. Both ways can work very well, but it is important to follow up with laboratory tests and / or an experienced professional.

After diluted, the HCG must be refrigerated for conservation and some experts claim that it can last for a few weeks, although the package insert recommends to keep for a maximum of 12h. It can be applied intramuscularly or subcutaneously. The general recommendation is to apply 3x in the week.

* PCT timing refers to the time required for the levels of synthetic steroids in the blood to be low enough not to cause axial suppression, so it is good to consider approximately 3-4x the drug's half-life to start PCT and / or evaluate LH, FSH and testosterone tests.

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