EXEMESTANE - PROFILE

Exemestane is a potent steroidal aromatase inhibitor that started to be marketed in 2000 under the trade name Aromasin, indicated for the treatment of breast cancer in postmenopausal women.

Exemestane is also a third generation aromatase inhibitor (the most potent and selective among AIs), as well as anastrozole and letrozole, but unlike these two exemestane it irreversibly inhibits the aromatase enzyme. This means that when the enzyme is turned on, it will be completely inactivated, even after stopping the use of the drug, and this has the advantage of avoiding the rebound effect of estrogen after the use of exemestane, since the body will take a certain time to synthesize new substances. enzymes.

The usual doses of exemestane vary from 12.5 to 25 mg per day (EOD) and in these doses exemestane can reduce aromatization by more than 90-95%; therefore, it is necessary to be cautious with the use of this drug. Bodybuilders like exemestane because it has a lower risk of rebound effect from estrogen than other AIs and can reduce estradiol (estrogen) levels very effectively, but it is also the most expensive among AIs. In addition, all AIs do the same function (inhibit aromatization) and, even with different potencies, just an adjustment of the dose and knowledge of how the drug works in your body, to get good results with any of them. That is why monitoring estradiol concentrations is important, avoiding values ​​of this hormone below 20 pg / ml, and higher levels may be desirable if the lipid profile is severely impaired by androgenic steroids.

Very low levels of estrogen can negatively affect sexual function (libido, erection) and lipid profile, causing fatigue and joint pain. Some gurus consider it a good drug to be used in PCT (Anthony Roberts) in conjunction with SERMs and HCG, as long as estradiol levels are high in the post-cycle, as the reduction in estradiol concentrations stimulates the release of LH and FSH gonadotropins by the pituitary gland, consequently stimulating the production of testosterone and spermatogenesis in the testicles.

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