ANAVAR (OXANDROLONE) - PROFILE

Oxandrolone is a derivative of DHT, 17 AA, class 1 (strong binding to the androgen receptor, AR).

Oxandrolone was first synthesized by Raphael Pappo of Searle Laboratories, now Pfizer Inc., marketed under the name Anavar, and introduced in the United States in 1964. It is a synthetic anabolic steroid derived from dihydrotestosterone (DHT), with an oxygen atom replacing the 2nd carbon and methylation in position 17. Anavar has been prescribed to promote muscle growth in diseases that cause involuntary weight loss, and is used as part of the treatment for HIV / AIDS. It had also been shown to be partially successful in treating cases of osteoporosis. However, partly due to the bad publicity of its abuses by bodybuilders, the production of Anavar was discontinued by Searle in 1989. It started to be marketed by Bio-Technology General Corporation, now Pharmaceuticals Savient, which, after successful clinical trials in 1995, launched the drug with the trade name Oxandrin [1].
Oxandrolone is a low androgenic and moderately anabolic drug, with good aesthetic effects and gains without retention and solids, so it is an excellent drug for definition cycles, with the addition of being a good drug for burning fat (even superior to testosterone) [two]. Its low androgenicity and hepatotoxicity makes it a tolerated drug even at high dosages of ~ 100 mg per day, and is also little suppressive to the HPT axis. Oxandrolone, used at a dose of 20 mg / day, suppressed endogenous testosterone production by 67% after 12 weeks of therapy [3]. Studies have shown a rebound effect of LH (luteinizing hormone) after using it, reaching values ​​higher than those recorded before suppression [4]. Serum IGF-1 concentrations increased during treatment with oxandrolone and continued to increase after treatment ceased [5]. Oxandrolone also does not flavor or convert to DHT.
Oxandrolone is also an excellent drug for strength gain, since it increases the synthesis of phosphocreatine, quickly increasing the recovery of the ATP reserve and its availability, enabling more intense workouts. It also seems to improve breathing capacity, being a good drug for martial arts practitioners [6].
The most commonly reported doses range from 20 mg to 100 mg daily, with 60-70 mg being a good dose if the goal is a cycle with quality gain, especially if combined with other drugs, such as testosterone and / or some class 2 steroid. with which it presents good synergy (oximetolon, dianabol, stanozolol) [7]. Because it is little suppressive and generates solid gains, oxandrolone is a good drug to be used in bridges between cycles and even in a part of the CPT, in order to help insure the gains achieved during the cycle. In this case, doses of ~ 10-30 mg would be sufficient.
Because it is not androgenic and has good aesthetic and anabolic effects, oxandrolone is usually the drug of choice for women, with the risk of virilization being very low with this drug. Cycles usually last ~ 6-8 weeks at the most effective reported doses of ~ 20-30 mg per day.

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